Researchers discover protein that may control the spread of cancer

Tuesday, February 26, 2013

Researchers at the University of Hawai'i Cancer Center have uncovered a novel mechanism that may lead to more selective ways to stop cancer cells from spreading. Associate Professor Joe W. Ramos PhD, a cancer biologist at the UH Cancer Center and his team have identified the role of the protein RSK2 in cancer cell migration, part of the process of cancer metastasis.

Cancer becomes metastatic when cells break away from the primary tumor and spread to other parts of the body. Metastatic cancer is much more difficult to treat and patients with metastatic cancer have a generally worse prognosis. "The cancers that kill are those that spread to other parts of the body or disseminate within the organ," said Ramos. "If we could keep cancer cells confined to the primary tumor mass, we could remove it with less risk of metastasis and later recurrence."

The Ramos team reports that RSK2 significantly increases cell migration in part by reducing integrin activation. Integrins play an important role in cell adhesion to their surrounding tissue and the migration of tumor cells to new locations in the body. RSK is active in both breast and prostate tumors, and promotes proliferation in these cells. It can also promote cell invasion and metastasis in head and neck cancers in addition to lung cancer and neuroblastoma.

"We focused on understanding the process of cell adhesion," said Ramos. "Integrins help the cell move by grabbing onto proteins and cells in their surroundings, pulling, then releasing and grabbing on again. Blocking a cancer cell's ability to adhere and move can control further dissemination of some metastasis. There are drugs that kill cancer cells and there are drugs that stop the division of cancer cells, but there are far fewer drugs that specifically stop the movement of cancer cells. Our work suggests that drugs that interfere with RSKs may help control or prevent metastasis."

###

The study: "RSK2 Protein Suppresses Integrin Activation and Fibronectin Matrix Assembly and Promotes Cell Migration" is published in the December 21, 2012 edition of The Journal of Biological Chemistry. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527930/

University of Hawaii Cancer Center: http://www.uhcancercenter.org/

Thanks to University of Hawaii Cancer Center for this article.

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Source: http://www.labspaces.net/127024/Researchers_discover_protein_that_may_control_the_spread_of_cancer

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Celebrity Couples That Chose To Elope! (Photos)

Celebrity Couples That Chose To Elope! (Photos)

Not all celebrities want lavish, over-the-top weddings. Some Hollywood couples decide to skip the wedding-planning madness to run off and marry and party with friends and family later. Let’s check out some celebrity couples that chose to elope and see who lasted and who didn’t! Salma Hayek & Francois-Henri Pinault Actress Salma Hayek eloped with ...

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Source: http://stupidcelebrities.net/2013/02/celebrity-couples-that-chose-to-elope-photos/

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Opera WebKit-based browser hands-on

Think Opera is content at 300 million? That would be a rather silly notion for any company, of course, and naturally the browser is bumping up its efforts by making the jump to WebKit. This move will make Opera even more tempting for Android (phone and tablet) users who would never have given the browser even a sideways glance previously. The newer, fancier Opera throws in a few extra features. First, there's a launch page called speed dial that looks an awful lot like what we've seen in older versions; you can customize a bunch of shortcuts and links based on your overall usage and personal preferences, and toss all of them in folders. There's also an off-road mode, which essentially gives you the option to switch over to Opera Mini for extra data compression for those times you need it -- this obviously comes in handy when you're reaching your data threshold or just in a low-reception area. Lastly, HTML5 support is built in, as we would come to expect with a new browser these days.

Though we were originally told in January that we could expect Android and iOS versions of the browser sometime this month, representatives at the company's booth at MWC noted that what we're seeing is actually a pre-beta version and the final product is "coming soon" with no specific timetable given. This doesn't surprise us, as the demonstration had its fair share of bugs, but we will reserve judgment until we see it in its final form. As we patiently wait for the browser to make its public appearance, you can pine for it by drooling over the images in our gallery below.

Gallery: Opera WebKit-based browser-hands-on

Sean Cooper contributed to this hands-on.

Filed under: Cellphones, Software, Mobile, Google

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/-L20IOIePrk/

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MWC 2013: LG Launches LG WCP-300 World's Smallest Wireless ...

LG has announced the LG WCP-300 world?s smallest wireless charger at MWC. It is only 6.9cm in diameter and company claims it is designed with portability in mind.

It uses a standard 5-pin micro USB charger to bring juice to the wireless pad. LG is calling the wireless charger the WCP-300 and it is compatible with the Nexus 4. The pad has also been Qi certified by the Wireless Power Consortium, which means that it will work properly.

?With the WCP-300, LG was able to deliver both portability with top-class charging capabilities in a device no larger than a typical beverage coaster.? said Jong-seok Park, president and CEO of LG Electronics Mobile Communications Company.

?Wireless charging is the holy grail of smartphone user convenience,? Dr. Jong-seok Park, President and CEO of LG Electronics Mobile Communications Company said in a press release.

?With the WCP-300, LG was able to deliver both portability with top-class charging capabilities in a device no larger than a typical beverage coaster,? he added.

LG is committed to offering consumers a better mobile user experience by introducing smartphones with more advanced wireless charging technologies in the global market.

Press Release:

LG INTRODUCES WORLD?S SMALLEST WIRELESS CHARGER
LG?s Thin and Sleek Wireless Charger Delivers Maximum Charging Performance and User Convenience

BARCELONA, Feb. 26, 2013 ? LG Electronics (LG) today introduced the world?s smallest wireless charger at Mobile World Congress (MWC) in Barcelona. At only 6.9cm in diameter, the WCP-300 is designed with portability in mind. Despite its di-minutive size, the charging area is 1.7 times wider than that of LG?s previous generation wireless charger. The new model is compatible with a standard 5-pin micro-USB charger, providing the highest level of charging performance and user convenience.

The WCP-300 employs electromagnetic induction technology and is Qi certified by the Wireless Power Consortium. Electromagnetic induction produces a magnetic field that in turn generates an electric current to charge the batteries in devices placed on the charging pad. Certification ensures that the WCP-300 is compatible with all smart-phones that support the Qi standard.

?Wireless charging is the holy grail of smartphone user convenience,? said Dr. Jong-seok Park, President and CEO of LG Electronics Mobile Communications Company. ?With the WCP-300, LG was able to deliver both portability with top-class charging capabilities in a device no larger than a typical beverage coaster.?

In the US market, both the LG Spectrum 2 and Nexus 4 feature built-in support for wireless charging right out of the box, eliminating the need to purchase separate covers. LG believes that built-in support for upcoming smartphones will be the most critical development in making wireless charging the industry standard going forward.

LG is committed to offering consumers a better mobile user experience by introducing smartphones with more advanced wireless charging technologies in the global market.

About LG Electronics, Inc.

LG Electronics, Inc. (KSE: 066570.KS) is a global leader and technology innovator in consumer electronics, mobile communications and home appliances, employing more than 93,000 people working in over 120 operations around the world. With 2012 global sales of USD 45.22 billion (KRW 50.96 trillion), LG comprises four business units ? Home Entertainment, Mobile Communications, Home Appliance, and Air Conditioning & Energy Solution ? and is one of the world?s leading producers of flat panel TVs, mobile devices, air conditioners, washing machines and refrigerators. LG Electronics is a 2012 ENERGY STAR Partner of the Year. For more news and information on LG Electronics, please visit www.LGnewsroom.com.

Source: http://cellphonequick.com/lg-wcp-300-worlds-smallest-wireless-charger/

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Kim Clijsters Expecting Second Child

Kim Clijsters and her husband Brian Lynch are expecting their second child in September, she announced on Twitter Monday.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/996I3HMU1YE/

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C. Everett Koop, ex-surgeon general, dies in NH

C. Everett Koop, who raised the profile of the surgeon general by riveting America's attention on the then-emerging disease known as AIDS and by railing against smoking, has died in New Hampshire at age 96.

An assistant at Koop's Dartmouth institute, Susan Wills, said he died Monday in Hanover, where he had a home. She didn't disclose his cause of death.

Koop wielded the previously low-profile post of surgeon general as a bully pulpit for seven years during the Ronald Reagan and George H.W. Bush administrations.

An evangelical Christian, he shocked his conservative supporters when he endorsed condoms and sex education to stop the spread of AIDS.

He carried out a crusade to end smoking in the United States ? his goal had been to do so by 2000. A former pipe smoker, he said cigarettes were as addictive as heroin and cocaine.

Koop's impact was great, although the surgeon general has no real authority to set government policy. He described himself as "the health conscience of the country."

"My only influence was through moral suasion," Koop said just before leaving office in 1989.

By then, his Amish-style silver beard and white, braided uniform were instantly recognizable.

Out of office, he switched to business suits and bow ties but continued to promote public health causes, from preventing childhood accidents to better training for doctors.

"I will use the written word, the spoken word and whatever I can in the electronic media to deliver health messages to this country as long as people will listen," he promised.

In 1996, he rapped Republican presidential hopeful Bob Dole for suggesting that tobacco is not invariably addictive, saying Dole's comments "either exposed his abysmal lack of knowledge of nicotine addiction or his blind support of the tobacco industry."

Although Koop eventually won wide respect with his blend of old-fashioned values, pragmatism and empathy, his nomination in 1981 met a wall of opposition from women's groups and liberal politicians.

Critics said Reagan selected Koop, a pediatric surgeon from Philadelphia, only because of his conservative views, especially his staunch opposition to abortion.

Foes noted that Koop traveled the country in 1979 and 1980 giving speeches that predicted a progression "from liberalized abortion to infanticide to passive euthanasia to active euthanasia, indeed to the very beginnings of the political climate that led to Auschwitz, Dachau and Belsen."

But Koop, a devout Presbyterian, was confirmed after he told a Senate panel he would not use the surgeon general's post to promote his religious ideology. He kept his word.

In 1986, he issued a frank report on AIDS, urging the use of condoms for "safe sex" and advocating sex education as early as third grade.

He also maneuvered around uncooperative Reagan administration officials in 1988 to send an educational AIDS pamphlet to more than 100 million U.S. households, the largest public health mailing ever done.

Koop personally opposed homosexuality and believed sex should be saved for marriage. But he insisted that Americans, especially young people, must not die because they were deprived of explicit information about how the HIV virus was transmitted.

He became a hero to AIDS activists, who chanted "Koop, Koop" at his appearances but booed other officials.

Koop further angered conservatives by refusing to issue a report requested by the Reagan White House, saying he could not find enough scientific evidence to determine whether abortion has harmful psychological effects on women.

Koop maintained his personal opposition to abortion, however. After he left office, he told medical students it violated their Hippocratic oath. In 2009, he wrote Senate Majority Leader Harry Reid urging that health care legislation include a provision to ensure doctors and medical students would not be forced to perform abortions. The letter briefly set off a security scare because it was hand delivered.

Koop served as chairman of the National Safe Kids Campaign and as an adviser to President Bill Clinton's health care reform plan.

At a congressional hearing in 2007, Koop spoke about political pressure on the surgeon general post. He said Reagan was pressed to fire him every day, but Reagan would not interfere.

Koop, worried that medicine had lost old-fashioned caring and personal relationships between doctors and patients, opened an institute at Dartmouth to teach medical students basic values and ethics.

He also was a part-owner of a short-lived venture, drkoop.com, to provide consumer health care information via the Internet. It made its initial public offering of stock in 1999, but expenses outstripped revenue and it was out of business by the end of 2001.

In July 2001, the company agreed to pay $4.25 million in cash to settle lawsuits filed by investors who claimed drkoop.com made false promises. Company officials did not admit wrongdoing.

Koop was born in New York's borough of Brooklyn, the only son of a Manhattan banker and the nephew of a doctor. He said by age 5 he knew he wanted to be a surgeon and at age 13 he practiced his skills on neighborhood cats.

He attended Dartmouth College, where he received the nickname Chick, short for "chicken Koop." It stuck for life.

He received his medical degree at Cornell Medical College, choosing pediatric surgery because so few surgeons practiced it.

In 1938, Koop married Elizabeth Flanagan, the daughter of a Connecticut doctor. They had four children ? Allen, Norman, David and Elizabeth. David, their youngest son, was killed in a mountain-climbing accident when he was 20.

Koop was appointed surgeon-in-chief at Children's Hospital in Philadelphia and he also served as a professor at the University of Pennsylvania School of Medicine.

He pioneered surgery on newborns and successfully separated three sets of conjoined twins. He won national acclaim by reconstructing the chest of a baby born with the heart outside the body.

Although raised as a Baptist, he was drawn to a Presbyterian church near the hospital, where he developed an abiding faith. He began praying at the bedside of his young patients ? ignoring the snickers of some of his colleagues.

"It used to be said in World War II that there were no atheists in foxholes," he wrote in 1973. "I have found there are very few atheists among the parents of dying children.

"This is a time when religious faith can see a family through trying circumstances."

___

Ring reported from Montpelier, Vt. Cass reported from Washington.

Source: http://news.yahoo.com/c-everett-koop-ex-surgeon-general-dies-nh-215926071.html

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Insert Coin semifinalist: SmartKnob brings keypad access to your front door

Keys? Who needs keys? The Smart Knob is an attempt to do away with those pesky metal things for property managers and renters, attaching a keypad to your front door's deadbolt. Owners of the property can issue codes remotely for a chosen period of time. Visitors can also get codes by calling the service's automated phone system. The Smart Knob is compatible with all standard circular deadbolts, and its creators insist that the installation process takes under a minute. The battery should last "up to two years" with daily use -- and when it gets low, a warning will let you know.

Check out a video of the original plastic prototype after the break. The final version will, thankfully, be made of metal.

Check out the full list of Insert Coin: New Challengers semifinalists here -- and don't forget to pick a winner!

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Source: The Smart Knob

Source: http://www.engadget.com/2013/02/24/insert-coin-smartknob/

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Fence repaired, Daytona 500 will go on

DAYTONA BEACH, Fla. ? Neither NASCAR nor Daytona International Speedway has a lot of answers following the horrific crash at the conclusion of Saturday's Nationwide Series race that sent shards of metal and two tires flying into the stands injuring at least 28 fans.

The prevailing sentiment offered from NASCAR's vice president of operations Steve O'Donnell and track president Joie Chitwood was they don't have a lot of answers, they're going to look into the situation and they'll do whatever they can to create an even safer environment in the future.

Rescue workers respond next to a hole in the catchfence. (REUTERS)Track officials worked into the early morning Sunday to repair the hole ripped in the catchfence following the 12-car accident on the final lap of the Race4COPD 300. Work was completed at 2 a.m. ET. Chitwood and O'Donnell met at 8 a.m. Sunday morning to review the repairs, are confident they are satisfactory and the 55th running of the Daytona 500 will start on time, at 1:30 p.m.

Asked if the speedway would consider moving fans further away from the track for Sunday's race, Chitwood said no.

"We have over 100,000 seats on the frontstretch, I think we've got very good safety protocol," Chitwood said. "We had a structural engineering firm come in to look at our fencing, and based on their recommendations we installed a new fence.

"Incidents do happen, and I think that those are the exception, though. If you look at our 55 years of business, we have a pretty good safety record."

While it appears on video one of the tires flew over the 22-foot fence, Chitwood said they have not yet determined how it ended up nine rows into the stands. He did confirm that several fans were injured in the second level.

"I think we sit down and review everything in terms of what happened," Chitwood said. "I think NASCAR from a competition perspective will continue to address that, and we'd be happy, too."

[Related: Daytona crash scene in the stands resembled 'war zone']

When posed with the question about the future of racing at Daytona, where speeds reach 200 m.p.h., O'Donnell said the future of NASCAR's most famous track is not in doubt.

"We're very confident that we'll be racing here," he said. "Obviously, like I said, it's something we look at after every race. Unfortunately incidents take place at other tracks as well that we review. Daytona is a place we will be at."

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Source: http://sports.yahoo.com/news/nascar--fence-repaired--daytona-500-will-go-on--nascar-searching-for-answers-152728165.html

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Red Wing's mayor resigns in face of pressure over his frac sand industry role (Star Tribune)

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Syrian Opposition Pulls Out of International Talks (Voice Of America)

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Not Rising, But Rejuvenating: The ?Chinese Dream? Many talk of China "rising."...

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State may brand illegal immigrants' driver's licenses

North Carolina Department of Motor Vehicles via WCNC

The new North Carolina license declares to everyone that the bearer has "no lawful status."

By The Associated Press

RALEIGH, N.C. ? A new North Carolina driver's license set to be issued to some illegal immigrants has a bright pink stripe and the bold words "NO LAWFUL STATUS," raising concerns about whether the design will brand those who show it.

The North Carolina Division of Motor Vehicles announced last week that it would begin issuing the licenses March 25 following a lengthy legal review. The Obama administration's Deferred Action for Childhood Arrivals program grants valid federal work permits to qualified applicants brought to the U.S. as children without legal authorization.

---

Some Republican lawmakers in the state have balked at the idea, filing a bill Thursday to bar the DMV from granting the licenses until at least June.

Cinthia Marroquin, 22, of Raleigh, ?head organizer for NC DREAM Team, an immigrant rights group, is?awaiting approval for a DACA permit. She said the longer the license issue is delayed, the longer it will take for her to get a job and drive herself to work. Even if she is able to get one, she is worried about presenting a license declaring she has "NO LAWFUL STATUS" at a police roadblock or while writing a check at the grocery store.

"A lot of us are just scared," said Marroquin, who came to the U.S. from Mexico when she was 15. "We just want to be able to get a job and drive to work. Having that license is just going to show everybody you're here illegally, just buying a beer or writing a check. You don't know how people might react."

The American Civil Liberties Union of North Carolina also takes issue with the designation.

"North Carolina should not be making it harder for aspiring citizens to integrate and contribute to our communities by branding them with a second-class driver's license," said ACLU attorney Raul Pinto. "There is simply no reason for officials to stigmatize people who are in the U.S. legally with an unnecessary marker that could lead to harassment, confusion, and racial profiling."

Almost from the moment President Barack Obama announced the program in June, states across the country grappled with how and whether to issue driver's licenses to those granted legal presence.

Watch US News videos on NBCNews.com

The U.S. Department of Homeland Security has said it is up to officials in each state to make their own determination about what to do. Many states, including Oregon and Georgia, have announced that they will grant driving privileges to those eligible.

In Arizona, where Republican Gov. Jan Brewer has pledged that DACA youths will not get driver's licenses, the state's DMV still lists federal work permits among the documents making people eligible for one.

The issue is especially politically charged in North Carolina, where current state law ordains a driver's license will be issued to anyone who holds valid federal documentation of their "legal presence" in the United States.

The office of the state's Democratic attorney general in an opinion last month said that under federal law, DACA participants have a "legal presence," even if they do not have "lawful status." Therefore, state law requires that DACA participants be granted licenses. Republican Gov. Pat McCrory's administration agreed, announcing last week the DMV would begin issuing the licenses.

That has upset many conservatives in McCrory's own party, including Rep. Mark Brody, R-Union. He is one of four freshmen legislators who introduced a bill Thursday to bar the DMV from issuing licenses to DACA participants before June 15, potentially giving time to craft a permanent change to state law.

Brody said he believes strongly that the DACA program violated the U.S. Constitution because it was implemented without congressional approval. Obama said last year he was forced to take executive action by the decades-long failure of Congress to consider meaningful immigration reform.

"We need a time out," said Brody, a construction contractor. "We don't need to have the federal government dictating to us how we are supposed to issue licenses in this state. We do it, and that's a privilege we have under our Constitution."

Among the concerns raised by Brody and other bill sponsors is that illegal immigrants might use their new licenses to access social programs or register to vote, despite the bright pink markings. An extensive 2011 review of the state's 6.4 million registered voters by the N.C. Board of Elections found 12 instances where a non-citizen successfully cast a ballot.

Jose Rico, a 23-year-old Raleigh resident from Mexico who has already been issued DACA work permit, said he plans to be in line at the DMV on March 25 to get a license, even if it's pink. He will be extremely disappointed if state legislators pass a bill delaying or a denying his ability to do so.

"I don't know what's wrong with these people, why they're so afraid of people like me," said Rico, who has lived in the U.S. since he was 13. "It's so frustrating. I passed a federal background check, done everything right by the book. I'm paying taxes. I mean, we're just kids trying to go to school."

Associated Press writer Gosia Wozniacka contributed from Fresno, Calif.

Related:
Majority of citizens believe illegal immigrants should be deported

? 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://usnews.nbcnews.com/_news/2013/02/22/17061005-pink-stripe-on-illegal-immigrants-drivers-licenses-considered-in-nc?lite

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College students to spend spring break with Horry County's Habitat for Humanity

MYRTLE BEACH, SC (WMBF) ?Students will be volunteering for Habitat for Humanity of Horry County during their spring breaks.

The Collegiate Challenge, Habitat's national alternative break program, has 36 students participating this year.

Visiting from Eastern Kentucky University, Vanderbilt University and Alfred State College during the weeks of March 4-23, the students will help revitalize homes for families who've been in the Habitat for Humanity program for quite some time.

Gail Olive, the Executive Director for Horry County's Habitat for Humanity, says she looks forward to hosting the student volunteers once again.

"Collegiate Challenge provides the students with an opportunity to help build affordable housing in the area," Olive said. "The work they will do during their spring break will have a lasting impact in our community."

The sponsor for the program this year is Ripley's Aquarium, and several local restaurants, churches, and organizations are helping the cause by donating meals to the Collegiate Challenge volunteers. T-Bonz will be providing a lunch each week, while Mellow Mushroom has agreed to donate a dinner.

For more information, visit Habitatmb.org.

If you would like to be a part in hosting and welcoming these students to the community, please send an email to volunteer@habitatmb.org.

Copyright 2013 WMBF News. All rights reserved.

Source: http://myrtlebeach.wmbfnews.com/news/news/50727-college-students-spend-spring-break-horry-countys-habitat-humanity

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Rapper, cabbie meet violent end together in Vegas

LAS VEGAS (AP) ? Kenny Cherry was an aspiring rapper who moved from the Bay Area to Las Vegas to pursue his career. His music videos online show him cruising the Strip in his Maserati.

Michael Boldon was a family man and taxi driver who hailed from Michigan and loved fast cars.

The two men's lives ? along with that of an unidentified passenger in Boldon's cab ? ended in violence normally seen only in movies: gunfire, a fiery crash and an explosion before dawn Thursday on the neon-lit Las Vegas Strip.

As investigators Friday tried to find the gunman in a black Range Rover SUV who triggered the shocking chain of events, families and friends tried to grasp the blink-of-an-eye finality of it all.

"Right now my heart is breaking," said Cherry's great aunt, Patricia Sims, of Oakland, Calif. "This has really been a tragedy. Kenny was just a delightful kid."

Sims, 75, said Cherry moved to Las Vegas from Northern California, though she didn't know her nephew was a rapper using the name Kenny Clutch.

Cherry's parents were traveling to Las Vegas on Friday to claim his body. The 27-year-old, whose full name is Kenneth Wayne Cherry Jr., was driving a Maserati that was peppered by gunfire before it sped through a red light and smashed into Boldon's taxi.

The taxi exploded into flames, killing Boldon and female passenger Sandra Sutton-Wasmund, as four other vehicles crashed like pinballs at an intersection overlooked by some of Las Vegas' most famous hotel-casinos: Bellagio, Caesars Palace, Bally's and the Flamingo.

Police think an argument at the valet area of the upscale Aria resort-casino led to the shooting, but they haven't shared details. The shooting happened the same night that Morocco-born rapper French Montana was playing at Aria's signature nightclub, Haze.

"What the original disagreement was is crucial to the ongoing investigation and the identification of the suspects," said Las Vegas police officer Bill Cassell.

He said investigators were examining surveillance video and enlisting help from federal authorities and agencies in neighboring states to look for the distinctive Range Rover. It had blackout windows and custom black rims and was last seen speeding away from the fiery scene around 4:30 a.m. Thursday.

Police said a passenger in the Maserati was wounded in the arm but was treated at a hospital and released. He was reported to be cooperating with investigators, and his name wasn't made public.

Cherry's father, Kenneth Cherry Sr., of Emeryville, Calif., said he was struggling to handle his grief.

He said his son started a music career in Oakland after attending two Catholic high schools. According to his father, Cherry was recognized by other rappers within a West Coast hip-hop strain called hyphy.

Cherry was not well-known in wider music circles, according to Chuck Creekmur, CEO of AllHipHop.com.

"I had never heard his name before," Creekmur said.

Kenny Clutch's YouTube music video, "Stay Schemin," shows scenes of hotels along the Strip as he sings about paying $120,000 for his Maserati.

"One mistake change lives all in one night," he raps in one verse.

Cherry Sr. said he didn't know how his son made money or if he had any other jobs.

"I want to make it clear that my son was no gangster or nothing like that," he told The Associated Press. "He moved to Vegas about six year ago and he was writing music and rap."

Court records show Cherry had no criminal cases or convictions in Las Vegas, and Cassell said there was no record of arrests.

The police spokesman wouldn't say whether investigators determined if Cherry owned, rented or borrowed the Maserati. Cassell called that information "integral to the investigation."

Meanwhile, Boldon's family struggled to cope with his death.

"It's very devastating for us, for my family," said Tehran Boldon, 50, younger brother of the 62-year-old taxi driver. "Our family has no history of violence or gang membership that would predict losing a family member to such an event."

Boldon's sister, Carolyn Jean Trimble, said Boldon was a father, a grandfather and a car enthusiast. He was one of five children born and raised in Michigan, where he took care of his ailing father, who fought cancer, before moving to Las Vegas to be with his 93-year-old mother.

Bolden had owned a clothing store in Detroit and worked at a car dealership, his sister said. He began driving taxis after moving to Las Vegas about 1 1/2 years ago.

Boldon loved watching IndyCar and NASCAR races and drove a Mercedes when he wasn't in a cab. An avid car enthusiast, he tried to persuade Trimble to buy a Bentley, she said.

"Everybody just loved him," the older sister said. "When that car hit that cab, Mike had to be in there talking and laughing."

The irony that a man with a taste for beautiful cars was killed by a sports car wasn't lost on Trimble.

"He would be tickled to death: 'Damn, of all things, a Maserati hit me, took me out like that,'" she said. "I'm happy he didn't suffer."

The county medical examiner said both Boldon and his passenger, Sutton-Wasmund, died of blunt force injuries and that their deaths were being treated as homicides. The 48-year-old woman was from Maple Valley, Wash.

Besides Cherry's passenger, police said five people were treated for injuries after the six-vehicle crash. No one was said to face life-threatening injuries.

Jogger Eric Lackey snapped a cellphone photo of the blazing scene moments after the crash. Black smoke billowed from the flaming taxi, amid popping sounds from the fire.

The famously glowing, always-open Las Vegas Strip was closed for some 15 hours before reopening Thursday night. One Nevada Highway Patrol sergeant recalled a similarly long closure after the 1996 drive-by slaying of rapper Tupac Shakur.

That shooting ? involving assailants opening fire on Shakur's luxury sedan from a vehicle on Flamingo Road ? happened about a block away from Thursday's crash.

The Shakur killing has never been solved.

___

Contributing to this report were Associated Press writer Garance Burke in San Francisco; AP Music Writer Mesfin Fekadu in New York; and researchers Judith Ausuebel, Jennifer Farrar and Lynn Dombek in New York.

Source: http://news.yahoo.com/rapper-cabbie-meet-violent-end-together-vegas-230113908.html

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On key U.S. visit, Abe vows to bring back a strong Japan

WASHINGTON (Reuters) - Japanese Prime Minister Shinzo Abe brought a clear message to Washington on Friday: "I am back and so is Japan."

It was the core theme of a speech prepared for delivery to a major U.S. think tank after meeting U.S. President Barack Obama on his first trip to Washington since taking office in December in a rare comeback to Japan's top job.

Abe, whose troubled first term ended after just one year when he abruptly quit in 2007, has vowed to revive Japan's economy with a mix of hyper-easy monetary policy, big spending, and structural reform. The hawkish leader is also boosting Japan's defense spending for the first time in 11 years.

"Japan is not, and will never be, a tier-two country," Abe said in a prepared draft of the speech. "So today ... I make a pledge. I will bring back a strong Japan, strong enough to do even more good for the betterment of the world."

The Japanese leader stressed that his "Abenomics" recipe would be good for the United States, China and other countries.

The yen has lost around 10 percent of its value against the dollar since Abe took office, sparking concerns that Japan is trying to export its way out of recession.

"Soon, Japan will export more, but it will import more as well," Abe said in the speech. "The U.S. will be the first to benefit, followed by China, India, Indonesia and so on."

Abe reiterated that Japan would not bow to challenges to its sovereignty over tiny islets in the East China Sea that Tokyo controls but Beijing also claims. However, he said he did not want to escalate tensions in the territorial row with China.

"No nation should underestimate the firmness of our resolve. No one should every doubt the robustness of the Japan-U.S. alliance," the draft speech said. "At the same time, I have absolutely no intention of climbing up the escalation ladder ... The doors are always open on my side for the Chinese leaders."

At the White House, Abe told reporters Japan would deal with the dispute calmly.

"I explained that we have always been dealing with this issue ... in a calm manner," he said through a translator, while sitting next to Obama in the Oval Office.

"We will continue to do so and we have always done so," Abe said.

The United States says the islands - known as the Senkaku in Japan and the Diaoyu in China - fall under a U.S.-Japan security pact. But Washington is keen to avoid being dragged into any military clash over them and has signaled that it wants both sides to resolve the row peacefully.

Abe repeated that Japan would not provide any aid for North Korea unless it abandons its nuclear and missile programs and releases Japanese citizens abducted decades ago to help train spies.

Pyongyang admitted in 2002 that its agents had kidnapped 13 Japanese in the 1970s and 1980s. Five have been sent home, but Japan wants better information about eight who Pyongyang says are dead and others Tokyo believes were also kidnapped.

(Reporting by Kiyoshi Takenaka and Paul Eckert; Editing by David Brunnstrom)

Source: http://news.yahoo.com/japan-stimulus-mean-more-business-u-asia-abe-200154579.html

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Charlotte Church (musician, 1986)

With International record sales topping 10 million albums, Charlotte Church is the world's most successful classical crossover female artist. Born in Llandaff, Cardiff, on February 21, 1986, she became an international sensation with the release of her debut album, Voice Of An Angel, released just after she'd turned 13. That record, as did her 1999 self-titled second album and her 2000 Christmas collection Dream A Dream, achieved platinum status in the United States. Ms. Church's last album, Enchantment, was released in the autumn of 2001 and debuted at #15 on the Billboard Top 200 album chart.

Charlotte Church has garnered worldwide acclaim for offering audiences something completely unique-herself. It's a quality that comes across not only in the dynamics and diversity of her repertoire-which includes Broadway musicals, opera, chamber music, Gaelic airs and pop songs-but in the captivating charm and poise of this 16 year-old Welsh singing sensation. Charlotte Church not only has the voice of an angel, but a wicked flare for life.

Charlotte Church Facts

Selected Filmography

I'll Be There (2003) as Olivia

Source: http://www.filmbug.com/db/4142

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5 Olympians Who Went to Court

Oscar Pistorius, facing a charge of premeditated murder in the Valentine's Day slaying of his girlfriend, is one of several OIympians who found themselves in a courtroom for various accusations. Here are some the most famous:

MARION JONES

One of track and field's biggest stars at the 2000 Olympics, she won three gold medals and two bronzes in Sydney. Eight years later, Jones was serving time in a federal prison in Texas.

The former world's fastest woman was forced to return the medals to the International Olympic Committee after pleading guilty to lying to federal investigators about taking performance-enhancing drugs and her involvement in a check fraud scam. Jones served a six-month sentence from March-September 2008.

___

TIM MONTGOMERY

In 2002, Montgomery was the world's fastest man, dating Marion Jones and was an Olympic gold medalist with the United States 4x100-meter relay team at the 2000 Sydney Games. The Bay Area Laboratory Co-Operative scandal exposed his doping and subsequently led to his 9.78 seconds record time being dropped from the books.

Montgomery was later sentenced to almost 10 years jail time for his part in a $5 million check-fraud conspiracy ? which also ensnared Jones and his former coach Steve Riddick, a relay gold medalist at the 1976 Montreal Games ? and a conviction for dealing heroin in Virginia.

___

TONYA HARDING

Harding competed for the U.S. in figure skating at the 1994 Winter Olympics while under suspicion following an assault on her teammate and medal rival Nancy Kerrigan weeks before the games in Lillehammer, Norway.

Harding eventually was placed on probation after pleading guilty to helping cover up a conspiracy, involving her former husband, tied to an assault on Kerrigan before the national championships.

At the Olympics, Kerrigan won silver after recovering from her injuries; Harding finished eighth and was soon banned from the sport.

___

BRUCE KIMBALL

At the 1984 Los Angeles Olympics, Kimball won a diving silver for the U.S. in the 10-meter platform event.

Four years later, he was preparing for the national trials before the Seoul Olympics when he drove drunk at high speed into a group of partying teenagers in Hillsborough County, Fla., killing two.

Kimball, who competed at the trials and failed to qualify, pleaded guilty to two charges of drunken driving-manslaughter and was sentenced to 17 years in prison. He was released in November 1993 after serving nearly five.

___

GUY DRUT

Being an Olympic gold medalist eventually earned Drut a presidential pardon after the former French sports minister was found guilty in a political corruption case.

Drut, a 110-meter hurdler, won silver in 1972 at Munich, then added gold at the 1976 Montreal Olympics.

In 2005, a Paris court imposed a suspended sentence of 15 months on Drut for taking money from fictitious jobs linked to public construction contracts from 1990-92.

He was pardoned by President Jacques Chirac because of his distinguished service to French sport. The International Olympic Committee reprimanded him for conduct that "seriously tarnished the reputation of the Olympic Movement."

Source: http://news.yahoo.com/5-olympians-went-court-101935412--oly.html

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USU softball: Aggies set for weekend action in Texas Invitational

Utah State softball prepares for weekend action in the Texas Invitational in Austin, Texas.

USU will open tournament action on Friday, Feb. 15, against Southland Conference opponent Lamar at 10 a.m. (MT). The second game of the day on Friday for the Aggies, will be a matchup with Conference-USA foe, Tulsa at 1:30 p.m. (MT).

Utah State will square off with No. 6 and host-Texas on Saturday, Feb. 16 at 9:30 a.m. (MT). USU will not know its next opponent until tournament standings are finalized and semifinal games are set.

Fans can follow all of the weekend actions through GameTracker links that will be available on the USU website, as well as live streaming audio for a subscription fee.

Doug Hoffman is the assistant athletic director for Utah State University Athletic Media Relations.

Source: http://www.deseretnews.com/article/865573829/USU-softball-Aggies-set-for-weekend-action-in-Texas-Invitational.html

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Obama: Immigration leak didn't hurt Senate talks

WASHINGTON (AP) ? President Barack Obama sought Wednesday to mitigate any damage from the leak of an immigration bill being drafted by the White House, telling a Spanish-language TV network he didn't jeopardize negotiations with the Senate.

Leaks in Washington happen all the time, Obama said, and shouldn't prevent immigration reform from moving forward. He said negotiations are continuing at full speed.

Members of a bipartisan Senate group taking the lead on immigration reform were caught off-guard over the weekend when details of Obama's own bill were published on USA Today's website. Obama has in the past said he's prepping his own bill, but only as a back-up in case congressional talks fail.

Some Republicans have questioned whether the leak of a competing bill tied makes it more difficult to strike a deal in the Senate. Sen. Marco Rubio of Florida, one of the Republicans in the group, said Obama's plan injects partisanship into a tough process. And David Axelrod, a senior adviser to Obama's re-election campaign, acknowledged that it likely was a mistake for news of Obama's plan to be made public.

Obama said Wednesday he still prefers that Congress ? not the White House ? craft a viable law to overhaul the nation's immigration system, and that his standby bill doesn't intrude on the bill that senators are hashing out. He said the ideas included in his bill are consistent with the immigration proposals he has advocated for the past several years, meaning they shouldn't come as a surprise to members of either party.

Obama's comments came in an interview with KWEX, San Antonio's Univision affiliate and one of eight local TV stations to sit down with Obama on Wednesday at the White House. KWEX aired the interview in Spanish with a translation of Obama's remarks.

While Obama and the Senate group differ on some key details, both sides are contemplating legislation that would provide a pathway to citizenship for most of the 11 million illegal immigrants already in the U.S., tighten border security, crack down on businesses that employ illegal workers and strengthen the legal immigration system.

___

Llorca reported from El Paso, Texas.

Source: http://news.yahoo.com/obama-immigration-leak-didnt-hurt-senate-talks-015657204--politics.html

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Facebook, Google Founders Sponsor $33 Million Breakthrough Prize To Reward Life Science Research, Announce Inaugural Winners [FULL LIST]

The newly-created foundation will announce the first 11 winners of the award on Wednesday, who will then be asked to help choose the recipients for future prizes.

"Our society needs more heroes who are scientists, researchers and engineers," Zuckerberg wrote on his Facebook page on Wednesday. "We need to celebrate and reward the people who cure diseases, expand our understanding of humanity and work to improve people's lives."

The Facebook founder, Google co-founder and prominent venture capitalist, respectively, hope this prize will reenergize the medical field to continue their endeavors to research and battle cancer, Parkinson?s disease, and diabetes, among other medical maladies.?

"With the mapping of the genome sequence there are expectations of significant progress in the next 10 or 20 years so I think the timing is really appropriate to create an incentive for the best scientific minds," Milner told the Guardian.

The Breakthrough Prize in Life Sciences Foundation was also co-founded by Anne Wojcicki and Priscilla Chan, the wives of Brin and Zuckerberg, respectively, as well as Art Levinson, chairman at Apple.

?I am delighted to announce the launch of the Breakthrough Prize in Life Sciences and welcome its first recipients," Levinson said. ?I believe this new prize will shine a light on the extraordinary achievements of the outstanding minds in the field of life sciences, enhance medical innovation, and ultimately become a platform for recognizing future discoveries.?

The company is a not-for-profit corporation, which is not surprising considering each founder?s personal links to philanthropy and the life sciences:

Zuckerberg and Chan were both ranked No. 2 on the annual list of America?s Most Generous Donors ? behind only Warren Buffett -- both donating a whopping $3 billion in 2012; Zuckerberg may be too busy to stay focused on life sciences, but his wife Chan is focusing on a career in pediatrics.

?Priscilla and I are honored to be part of this,? Zuckerberg said. ?We believe the Breakthrough Prize in Life Sciences has the potential to provide a platform for other models of philanthropy, so people everywhere have an opportunity at a better future.?

Brin and his wife Wojcicki, who were both just two spots down on America?s Most Generous Donors list, donated a combined $222 million last year, with Wojcicki also investing a great deal of her time at genomics firm 23andMe, a company she co-founded in 2006.

?We are thrilled to support scientists who think big, take risks and have made a significant impact on our lives,? Wojcicki said. ?These scientists should be household names and heroes in society.?

?Curing a disease should be worth more than a touchdown,? Brin added.

Milner, who founded Digital Sky Technologies in 2005, said he had personal reasons for helping jumpstart The Breakthrough Prize in Life And Sciences Foundation.

"I have two very close relatives with very bad diseases, one of them is cancer," Milner told The Guardian. ?This is part of my personal connection with this prize."

All winners of the Breakthrough Prize will be invited to give a presentation ?targeting a general audience,? which will be made available to the public to help keep citizens informed on the latest developments in the science and medical fields.

?Solving the enormous complexity of human diseases calls for a much bigger effort compared to fundamental physics and therefore requires multiple sponsors to reward outstanding achievements,? Milner said.

Here is the full list of this year?s inaugural winners, courtesy of The Breakthrough Prize in Life Sciences Foundation:

????????? Cornelia I. Bargmann

Torsten N. Wiesel Professor and Head of the Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior at the Rockefeller University. Howard Hughes Medical Institute Investigator.

For the genetics of neural circuits and behavior, and synaptic guidepost molecules

????????? David Botstein

Director of the Lewis-Sigler Institute for Integrative Genomics and the Anthony B. Evnin Professor of Genomics at Princeton University.

For linkage mapping of Mendelian disease in humans using DNA polymorphisms.

????????? Lewis C. Cantley

Margaret and Herman Sokol Professor and Director of the Cancer Center at Weill Cornell Medical College and NewYork-Presbyterian Hospital.

For the discovery of PI 3-Kinase and its role in cancer metabolism.

????????? Hans Clevers

Professor of Molecular Genetics at Hubrecht Institute.

For describing the role of Wnt signaling in tissue stem cells and cancer.

????????? Titia de Lange

Leon Hess Professor, Head of the Laboratory of Cell Biology and Genetics, and Director of the Anderson Center for Cancer Research at the Rockefeller University.

For research on telomeres, illuminating how they protect chromosome ends and their role in genome instability in cancer.

????????? Napoleone Ferrara

Distinguished Professor of Pathology and Senior Deputy Director for Basic Sciences at Moores Cancer Center at the University of California, San Diego.

For discoveries in the mechanisms of angiogenesis that led to therapies for cancer and eye diseases.

????????? Eric S. Lander

President and Founding Director of the Eli and Edythe L. Broad Institute of Harvard and MIT. Professor of Biology at MIT. Professor of Systems Biology at Harvard Medical School.

For the discovery of general principles for identifying human disease genes, and enabling their application to medicine through the creation and analysis of genetic, physical and sequence maps of the human genome.

????????? Charles L. Sawyers

Chair, Human Oncology and Pathogenesis Program at Memorial Sloan-Kettering Cancer Center. Howard Hughes Medical Institute Investigator.

For cancer genes and targeted therapy.

????????? Bert Vogelstein

Director of the Ludwig Center and Clayton Professor of Oncology and Pathology at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center. Howard Hughes Medical Institute Investigator.

For cancer genomics and tumor suppressor genes.

????????? Robert A. Weinberg

Daniel K. Ludwig Professor for Cancer Research at MIT and Director of the MIT/Ludwig Center for Molecular Oncology. Member, Whitehead Institute for Biomedical Research.

For characterization of human cancer genes.

????????? Shinya Yamanaka

Director of Center for iPS Cell Research and Application, Kyoto University. Senior Investigator, Gladstone Institutes, San Francisco.

For induced pluripotent stem cells.

?

Source: http://www.ibtimes.com/facebook-google-founders-sponsor-33-million-breakthrough-prize-reward-life-science-research-announce

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sprint-Blog ? Blog Archive ? Use The Internet For Your Business ...

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Source: http://sprint.medienhof-wedding.de/2013/02/19/use-the-internet-for-your-business-benefit-with-one-of-these-quick-ideas/

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Sars-like virus death reported in UK

19 February 2013 Last updated at 05:47 ET By James Gallagher Health and science reporter, BBC News

A patient infected with a new respiratory illness similar to the deadly Sars virus has died in the UK.

He was being treated at the Queen Elizabeth Hospital in Birmingham and died on Sunday morning, the hospital has confirmed.

Of the 12 people known to have been infected with the virus around the world, six have died.

The threat to the general population is thought to be small, although the virus has shown signs of spreading in people.

Three members of the same family have been infected with the virus in the UK as well as another patient who was flown in from Qatar for treatment.

It is thought one family member picked up the virus while travelling to the Middle East and Pakistan and then the virus spread to his son and another family member.

The son, who died, had a weakened immune system, which would have left him more vulnerable to the infection.

Continue reading the main story

Confirmed cases

Saudi Arabia: Five cases, three deaths

Jordan: Two cases, two deaths

UK: Four cases, one death

Germany: One case, flown from Qatar

Total: 12 cases, six deaths

Source: Health Protection Agency/World Health Organization

The hospital said it extended its sympathies to the family and was working with the Health Protection Agency to test other people who may have come into contact with the virus.

The infection causes pneumonia and sometimes kidney failure.

The exact source of the new virus and how it spreads is still unknown. The leading theory is that it comes from animals and the new Sars-like virus does appear to be closely related to a virus in bats.

The threat posed by the virus is thought to be low as it struggles to spread in people.

Speaking on Thursday, Dr Paul Cosford, deputy chief executive at the HPA, said: "It appears very difficult to catch"

Prof John Watson, head of the respiratory diseases department at the Health Protection Agency, said: "The routes of transmission to humans of the novel coronavirus have not yet been fully determined, but the recent UK experience provides strong evidence of human-to-human transmission in at least some circumstances.

"The three recent cases in the UK represent an important opportunity to obtain more information about the characteristics of this infection in humans and risk factors for its acquisition, particularly in the light of the first ever recorded instance of apparently lower severity of illness in one of the cases.

"The risk of infection in contacts in most circumstances is still considered to be low and the risk associated with novel coronavirus to the general UK population remains very low."

Prof Ian Jones, from the University of Reading, said: "Given the previous health status of the patient it may be premature to assume the death was a result of the infection but even if it was, it is unlikely to signify a change in the virus.

"No general virus spread has been reported meaning the risk to the public remains very low."

Source: http://www.bbc.co.uk/news/health-21503893#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Haunting, rare images depict WWI devastation

TORONTO, Feb 20 (Reuters) - Canada's Rebecca Marino, a rising star in women's tennis, stepped away from the sport in search of a normal life on Wednesday, weary of battling depression and cyber-bullies. Ranked number 38 in the world two years ago, the 22-year-old admitted she had long suffered from depression and was no longer willing to make the sacrifices necessary to reach the top. "After thinking long and hard, I do not have the passion or enjoyment to drive myself to the level I would like to be at in professional tennis," Marino explained in a conference call. ...

Source: http://news.yahoo.com/photos/haunting-rare-images-depict-wwi-devastation-slideshow/

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NY TV anchor accused of choking wife at Conn. home

DARIEN, Conn. (AP) ? A New York television news anchor has been accused of choking his wife at their Connecticut home and threatening her even after police arrested him.

Police say they received a call Sunday morning from WCBS-TV anchor Rob Morrison's mother-in-law about what was going on at the couple's home in Darien. They say Morrison had been belligerent toward CBS financial news anchor Ashley Morrison throughout the night and wrapped his hands around her neck.

The arresting officers say they heard him threaten to do her more harm while they were processing him. They say she didn't seek medical attention.

Rob Morrison has posted $100,000 bond and is due in court Tuesday. He faces charges including strangulation and disorderly conduct.

The Morrisons said Monday the allegations are "greatly exaggerated." Their attorney says they're cooperating fully with authorities.

Source: http://news.yahoo.com/ny-tv-anchor-accused-choking-wife-conn-home-030529872.html

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Emaar's sales outreach in India for Dubai-based properties record strong investor response

Among the inventory showcased are the newest project launches by Emaar in Downtown Dubai, including The Address Residence Fountain Views I and II; The Address The BLVD; Standpoint; CASA villas set in the Arabian Ranches extension; Panorama at The Views in Emirates Living; as well as inventory from its other residential and commercial portfolio in the city.

Ahmad Al Matrooshi, Managing Director, Emaar Properties, said: "The strong response from India is a testament to the confidence in Emaar's world-class projects, and in Dubai as a promising and long-term property investment destination. With our project launches in Dubai attracting customers from around the world, hosting special roadshows in international markets such as India, provides us the opportunity to engage with potential clients, and provide them the opportunity to make informed decisions on our projects."

He added: "For many Indians, the city serves as a second home, building on Dubai's appeal as the region's fastest growing shopping, tourism and business hub. Emaar's iconic developments open doors to a new lifestyle, as part of an integrated neighbourhood with all modern lifestyle amenities in close proximity."

According the Government of Dubai Land Department report, of the Dhs36bn investment by foreign investors in the city's property sector in 2012, 25% - valued at Dhs9bn - was by Indians. India is also the largest trading partner of Dubai, with total trade exchange valued at over Dhs126bn in the first 10 months of 2012. The city welcomed over 760,000 guests from India in 2012, with Dubai's airline, Emirates, operating some 185 weekly flights to 10 destinations in the country.

Emaar's flagship mega-development, Downtown Dubai, and its integrated communities such as Emirates Living, Arabian Ranches and Dubai Marina, serve as home to several expatriate Indian families. With Dubai's property sector recording robust growth, investors in Emaar's projects stand to benefit not only from the long-term investment value but also the rental yields.

Source: http://www.ameinfo.com/emaars-sales-outreach-india-dubai-based-properties-330335

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Watch Fall Out Boy + 2 Chainz Perform at the NBA All-Star Slam Dunk Contest

It confused a lot of people when 2 Chainz starred in Fall Out Boy?s video for ?My Songs Know What You Did in the Dark (Light ?Em Up)? video, but now it makes sense.

The recently-arrested rapper joined the band onstage for their performance at the NBA All-Star Slam Dunk contest for a remix of the track, and they killed it.

2 Chainz hopped onstage before the second verse, announcing his presence with the requisite ?2 Chaaaaaainz!? Promptly, the beat dropped and he spit his own verse, then lingered around onstage to sing along with Pete Wentz. Based on both their performance and everyone?s coordinating jerseys, we really hope 2 Chainz joins them on tour. They?re perfect together!

Next: Fall Out Boy Talk 2 Chainz Collabos

Source: http://popcrush.com/nba-all-star-slam-dunk-contest-fall-out-boy-2-chainz/

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